Pre-Clinical - Testing in Animals Director, DMPK Cambridge, MA

This position offers an exciting opportunity to be a key part of a research and development organization that is pioneering a new class of medicines. The Director, DMPK project representative, will provide direct support to multiple project teams across the discovery and early clinical development portfolio.

What you will be doing:

• Design and execute issue-driven ADME/PK studies to address critical discovery project needs, supporting program progression through lead optimization to early development
• Analyze and interpret preclinical ADME/PK data, communicating results and recommendations to project teams effectively
• Build and maintain strong collaborations with internal and external partners across chemistry, biology, pharmacology, CMC and other R&D disciplines
• Partner with discovery and clinical groups to design preclinical studies that inform clinical dosing strategy
• Contribute to key decisions including candidate selection, development strategy, and clinical trial design
• Author and review preclinical study reports, including nonclinical toxicology, DMPK and biomarker sections of regulatory documents
• Design and interpret PK/PD, efficacy and toxicology studies in collaboration with cross-functional teams
• Stay current with DMPK scientific literature and emerging technologies to identify potential applications for ongoing programs
• Help finalize clinical study protocols and reports with focus on DMPK aspects

Compensation Details:

• We provide a reasonable range of compensation for this position. Actual compensation is influenced by a wide array of factors including, but not limited to, skill set, level of experience and specific office location.
• The Pay Range for this position is $200k-$235k. It is possible that this position can be hired outside of this salary range based on experience.

EEO and Reasonable Accommodation Statement:

Orbis Clinical provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, housing, age, disability or genetics.

We will consider all qualified applicants for employment, including those with criminal histories, in a manner consistent with the requirements of applicable federal, state, and local laws.

By applying for this position, you agree that any calls from Orbis Clinical and its subsidiaries may be monitored or recorded for training and quality assurance purposes.